Prof. Giorgio Sartor

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HOME Anthropology Biochemistry of marine organisms Biomolecules Enzymes Membranes Proteins Biochemistry of pollutants Energy Lipids Metabolism SIGNAL TRANSDUCTION Cell Cycle Cytokines Receptors GROWTH FACTORS RECEPTORS G-Protein Coupled Receptors p53 Steroid Hormon Receptors Chronic Myeloid Leukemia Abl tyrosine protein kinase Abl tyrosine kinases in T-cell signaling ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Autoregulatory Mechanisms in Protein-tyrosine Kinases Binding specifcities and affinities of egf domains for ErbB receptors c-Abl Deficiency Provides Synaptic Resiliency Against Aß-Oligomers c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes Cutaneous side effects of epidermal growth factor receptor inhibitors: Clinical presentation, pathogenesis, and management Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells Development of Strategies to Manipulate ErbB Receptor Heterodimerization from a Quantitative Analysis of Receptor/Ligand Relationships Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways EGF-Receptor Tyrosine Kinase Inhibition Induces Keratinocyte Growth Arrest and Terminal Differentiation Emerging roles of Abl family tyrosine kinases in microbial pathogenesis Epidermal growth factor receptor (ERTK) signaling in cancer Epidermal growth factor stimulates tyrosine phosphorylation in the neonatal mouse: Association of a Mr 55,000 substrate with the receptor Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hairfollicle development and skin structure Extracellular domains drive homo- but not hetero-dimerization of erbB receptors Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules Functions and Mechanisms of Receptor Tyrosine Kinase Torso Signaling: Lessons From Drosophila Embryonic Terminal Development GEFs and GAPs: Critical Elements in the Control of Small G Proteins GEFs: master regulators of G-protein activation GTPase activating proteins: critical regulators of intracellular signaling Ligand-induced ErbB receptor dimerization Mechanisms of cutaneous toxicities to EGFR inhibitors Molecule of the Month: Epidermal Growth Factor Nuclear and Cytoplasmic Functions of Abl Tyrosine Kinase Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications Nuclear localization and possible functions of receptor tyrosine kinases Origin, Structure and Physiological Role of the Epidermal Growth Factor: A Review Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumorcells and normal human keratinocytes RAS-targeted therapies Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins Regulation of the catalytic activity of the EGF receptor RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility The Arg Non-receptor Tyrosine Kinase Modifies F-actin Structure The Capable ABL – What is its Biological Function? The discovery of receptor tyrosine kinases: targets for cancer therapy The Raf/MEK/ERK pathway: new concepts of activation The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase Tumor Necrosis Factor Alpha-Induced Apoptosis Requires p73 and c-ABL Activation Downstream of RB Degradation Small G proteins and their regulators in cellular signalling Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase The ErbB/HER receptor protein-tyrosine kinases and cancer Understanding SOS (Son of Sevenless) Untangling the ErbB Signalling Network Velvet, a Dominant Egfr Mutation That Causes Wavy Hair and Defective Eyelid Development in Mice What Kind of Rash Is It? Deciphering the Dermatologic Toxicities of Biologic and Targeted Therapies Archeology BIOCHEMISTRY Biology Chemistry Earth Sciences Medicine Physics Political Sciences Space Sciences Tools for sciences Books
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