Prof. Giorgio Sartor

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HOME Anthropology Biochemistry of marine organisms Biomolecules Enzymes Membranes PROTEINS Biochemistry of pollutants Energy Lipids Metabolism Signal transduction Antifreeze proteins Bioluminescence Heat Shock Proteins Oxygen Transport Proteins p53 Protein Structure PROTEIN TURNOVER Prions A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity A Ca2+ Switch Aligns the Active Site of Calpain A protein interaction network for pluripotency of embryonic stem cells A network of orthogonal ribosome-mRNA pairs Analysis of SUMOylated proteins using SUMO-traps Bacterial Heavy Metal Resistance: New Surprises Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity β-Puromycin Selection of Modified Ribosomes for in Vitro Incorporation of β-Amino Acids Chemistry and Biology of the Ubiquitin Signal Complete subunit architecture of the proteasome regulatory particle Controlling orthogonal ribosome subunit interactions enables evolution of new function Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation c-Abl Deficiency Provides Synaptic Resiliency Against Ab-Oligomers Defects in the Assembly of Ribosomes Selected for β‑Amino Acid Incorporation Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) Determination of Peptide Substrate Specificity for mu-Calpain by a Peptide Library-based Approach Drug discovery in the ubiquitin–proteasome system Dynamic personalities of proteins Dynamics of heat shock factor association with native gene loci in living cells Enlarging the Amino Acid Set of Escherichia coli by Infiltration of the Valine Coding Pathway Expanding SUMO and ubiquitin-mediated signaling through hybrid SUMO-ubiquitin chains and their receptors Expanding the Genetic Code of Escherichia coli HECT and RING finger families of E3 ubiquitin ligases at a glance Identification of substrates of the Mycobacterium tuberculosis proteasome Immunohistochemical localization of lysosomal cathepsin D in schwannomas In Vitro Assembly and Recognition of Lys-63 Polyubiquitin Chains In vitro ribosome synthesis and evolution through ribosome display In Vivo Biosynthesis of a β‑Amino Acid-Containing Protein Lysosomal membrane permeabilization in cell death Mechanisms Underlying Ubiquitination Modification in reverse: the SUMO proteases Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease Near-atomic resolution structural model of the yeast 26S proteasome One step beyond a ribosome: The ancient anaerobic core Origin and function of ubiquitin-like proteins Orthogonal translation enables heterologous ribosome engineering in E. coli Physiological functions of the HECT family of ubiquitin ligases Prime time for PROTACs Principles of ubiquitin and SUMO modifications in DNA repair Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States Protein delivery into eukaryotic cells by type III secretion machines Protein Modification by SUMO Protein synthesis by ribosomes with tethered subunits Reaching for high-hanging fruit in drug discovery at protein–protein interfaces Regulation of Protein-Protein Interactions by the SUMO and Ubiquitin Pathways Ribosome Subunit Stapling for Orthogonal Translation in E. coli Self-eating and self-killing: crosstalk between autophagy and apoptosis Sense codon reassignment enables viral resistance and encoded polymer synthesis Structural basis of ubiquitylation Structure and function of the ribosome - Nobel Lecture 2009 Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism Structures of Pup Ligase PafA and Depupylase Dop of the Prokaryotic Ubiquitin-like Modification Pathway SUMO: A History of Modification SUMO and transcriptional regulation SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? SUMO and ubiquitin paths converge SUMO: ligases, isopeptidases and nuclear pores SUMO protein modification SUMO-specific proteases: a twist in the tail SUMOylation: A Post-translational Modification Targeting Cytoskeletal Proteins Targeting the ubiquitin system in cancer therapy The biological impact of mass-spectrometry-based proteomics The calpain family and human disease The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition The emerging complexity of protein ubiquitination The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins The molecular sociology of the cell The origin of protein interactions and allostery in colocalization The pupylation pathway and its role in mycobacteria The Structure and Function of the Eukaryotic Ribosome The roles of intracellular protein-degradation pathways in neurodegeneration The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition The Ubiquitin System The Ubiquitin-Conjugating System: Multiple Roles in Viral Replication and Infection The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction The ubiquitylation machinery of the endoplasmic reticulum Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes in Vitro Ubiquitin and Membrane Protein Turnover: From Cradle to Grave Ubiquitination-mediated protein degradation and modification: an emerging theme in plant-microbe interactions Ubiquitin-binding domains Ubiquitin-independent proteolytic functions of the proteasome Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways Ubiquitylation in innate and adaptive immunity Unraveling the Complexity of Ubiquitin Signaling Archeology BIOCHEMISTRY Biology Chemistry Earth Sciences Medicine Physics Political Sciences Space Sciences Tools for sciences Books
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