Prof. Giorgio Sartor

HOME Desaturase My publications 3-Ketosteroid 9a-hydroxylase enzymes: Rieske non-heme monooxygenases essential for bacterial steroid degradation A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis A Function of Cytochrome b5 in Fatty Acid Desaturation by Rat Liver Microsomes single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation A Novel Cytochrome b5-like Domain Is Linked to the Carboxyl Terminus of the Saccharomyces cerevisiae D-9 Fatty Acid Desaturase An isothermal induction of Delta9-desaturase in cultured carp hepatocytes Applications of Stereospecifically-Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry Biochemical and physiological function of stearoyl-CoA desaturase Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases Biochemistry of the soluble methane monooxygenase Biosynthesis and Regulation of Microbial Polyunsaturated Fatty Acid Production Catalytic diversity of fatty acid desaturases Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates Control of fatty acid desaturation: a mechanism conserved from bacteria to humans Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate Deciphering the Cryptoregiochemistry of Oleate Delta12 Desaturase: A Kinetic Isotope Effect Study Decreasing stearoyl-CoA desaturase-1 expression inhibits b-catenin signaling in breast cancer cells Dihydrosterculic acid from cottonseed oil suppresses desaturase activity and improves liver metabolomic profiles of high-fat–fed mice Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes Desaturation and Hydroxylation Desaturation reactions catalyzed by soluble methane monooxygenase Dioxygen Activation at Non-Heme Diiron Centers: Oxidation of a Proximal Residue in the I100W Variant of Toluene/o-Xylene Monooxygenase Hydroxylase Eight Histidine Residues Are Catalytically Essential in a Membrane-Associated Iron Enzyme, Stearoyl-CoA Desaturase, and Are Conserved in Alkane Hydroxylase and Xylene Monooxygenase Effects of sterculic acid on stearoyl-CoA desaturase in differentiating 3T3-L1 adipocytes Enzymatic functionalization of carbon–hydrogen bonds Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation Evidence linking the Pseudomonas oleovorans alkane omega-hydroxylase, an integral membrane diiron enzyme, and the fatty acid desaturase family Exploring the Hydroxylation-Dehydrogenation Connection: Novel Catalytic Activity of Castor Stearoyl-ACP Delta9 Desaturase Exotic biomodification of fatty acids Fatty acid desaturases: selecting the dehydrogenation channel Fatty acid desaturation: variations on an oxidative theme Functional Mimic of Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Mechanistic Implications of Paramagnetic Intermediates in the Reactions between Diiron(II) Complexes and Dioxygen G2A as a receptor for oxidized free fatty acids Human cytochrome b5 reductase: Structure, function, and potential applications Hydroxystearic Acids and the Biosynthesis of Unsaturated Fatty Acids Inibition of Delta9-desaturase activity with sterculic acid: Effect on the endogenous synthesis of cis-9 18:1 and cis-9, trans-11 18:2 in dairy sheep INHIBITION OF THE MICROSOMAL STEAROYL COENZYME A DESATURATION BY DIVALENT COPPER AND ITS CHELATES Insights into Stearoyl-CoA Desaturase-1  Regulation of Systemic Metabolism Intermediate P* from Soluble Methane Monooxygenase Contains a Diferrous Cluster Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase Molecular mechanisms underlying catalytic activity of delta 6 desaturase from Glossomastix chrysoplasta and Thalassiosira pseudonana (SI1, SI2) Non-heme iron oxygenases Nutritional Regulation of Yeast A\-9 Fatty Acid Desaturase Activity Properties of Rat Liver Microsomal Stearoyl-Coenzyme A Desaturase Purification and Properties of Rat Liver Microsomal Stearyl Coenzyme A Desaturase Quantitation of hydroxylated byproduct formation in a Saccharomyces cerevisiae Delta9 desaturating system Recent insights into stearoyl-CoA desaturase-1 Regulation of Microsomal Stearoyl-Coenzyme A Desaturase Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol Regulation of stearoyl-CoA desaturases and role in metabolism Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions Revealing the catalytic potential of an acyl-ACP desaturase: Tandem selective oxidation of saturated fatty acids SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C  virus-induced specialized membranes Stearyl-CoA Desaturase of Bovine Mammary Microsomes Stearoyl-CoA desaturase-1 and adaptive stress signaling Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver Stearoyl-CoA desaturase and insulin signaling — What is the molecular switch? Stearoyl–CoA desaturase expression and fatty acid composition in milkfish (Chanos chanos) and grass carp (Ctenopharyngodon idella) during cold acclimation Stearoyl-CoA desaturase inhibitors: update on patented compounds Stereochemical Analysis of Sulfoxides Obtained by Diverted Desaturation Stereochemistry of Delta4 dehydrogenation catalyzed by an ivy (Hedera helix) Delta9 desaturase homolog Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation (Supplementary) Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis The association of desaturase 9 and plasma fatty acid composition with insulin resistance–associated factors in female adolescents The evolution of desaturases The Evolution of Fatty Acid Desaturases and Cytochrome b5 in Eukaryotes The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice The Metabolism of Hydroxystearic Acids in Yeast The Physiological Role and Control of Mammalian Fatty Acyl-Coenzyme A Desaturases The regulation of Delta-6 and Delta-9 desaturase in the fatty acid metabolism of hepatomas with different growth rate THE REGULATION OF STEAROYL-CoA DESATURASE (SCD) The Stereospecific Conversion of Stearic Acid to Oleic Acid The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation Two Δ6-desaturase-like genes in common carp (Cyprinus carpio var. Jian): Structure characterization, mRNA expression, temperature and nutritional regulation Up-regulated A9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: accumulation of a Delta9-desaturated metaboliteof tetradecylthioacetic acid X-ray structure of a mammalian stearoyl-CoA desaturase Links More Links Teaching material References
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