Prof. Giorgio Sartor

COVID-19

HOME Anthropology Links VIRUS STRUCTURE AND FUNCTION The Disease Social and Political Issues Vaccines and Therapies References A glycan gate controls opening of the SARS-CoV-2 spike protein - Supplementary - Video 1 - Video 2 - Video 3 - Video 4 - Video 5 A mechanistic evolutionary model explains the time-dependent pattern of substitution rates in viruses A structural analysis of M protein in coronavirus assembly and morphology ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis Atlas of coronavirus replicase structure Bat Coronaviruses in China Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677 Emerging coronaviruses: Genome structure, replication, andpathogenesis Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition Coronaviruses: An Overview of Their Replication and Pathogenesis Coronaviruses: genome structure, replication, and pathogenesis Coronavirus envelope protein: current knowledge Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020 Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets Good ACE, bad ACE do battle in lung injury, SARS Homologous recombination within the spike glycoprotein of the newly identified coronavirus 2019-nCoV may boost cross-species transmission from snake to human Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites Mapping of the Coronavirus Membrane Protein Domains Involved in Interaction with the Spike Protein Mechanism of SARS-CoV-2 polymerase stalling by remdesivir N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection Parallel evolution of influenza across multiple spatiotemporal scales Recurrent emergence and transmission of a SARS-CoV-2 spike deletion H69/V70 SARS coronavirus accessory proteins SARS-CoV-2 Cell Entry Depends on ACE2 andTMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor SARS-CoV-2 induces human endogenous retrovirus type W envelope protein expression in blood lymphocytes and in tissues of COVID-19 patients SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex SARS-CoV-2 spike P681R mutation enhances and accelerates viral fusion SARS-CoV-2 spike protein predicted to form stable complexes with host receptor protein orthologues from mammals SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC Severe acute respiratory syndrome coronavirus Orf3a protein interacts with caveolin Site-specific glycan analysis of the SARS-CoV-2 spike Structural basis of receptor recognition by SARS-CoV-2 Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers Structures and Functions of Coronavirus Proteins: Molecular Modeling of Viral Nucleoprotein Structure of replicating SARS-CoV-2 polymerase Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody Structure of the RNA-dependent RNA polymerase from COVID-19 virus Structure of the SARS-CoV nsp12 polymerasebound to nsp7 and nsp8 co-factors Supramolecular Architecture of Severe Acute Respiratory Syndrome Coronavirus Revealed by Electron Cryomicroscopy The Coronavirus E Protein: Assembly and Beyond The M, E, and N Structural Proteins of the Severe Acute Respiratory Syndrome Coronavirus Are Required for Efficient Assembly, Trafficking, and Release of Virus-Like Particles The M Protein of SARS-CoV: Basic Structural and Immunological Properties The major genetic risk factor for severe COVID-19 is inherited from Neanderthals The Molecular Biology of Coronaviruses The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag WITHDRAWN Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica) Archeology Biochemistry Biology Chemistry Earth Sciences Medicine Physics Political Sciences Space Sciences Tools for sciences Books
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