Prof. Giorgio Sartor

HOME 9HSA - All references My publications 3-Ketosteroid 9a-hydroxylase enzymes: Rieske non-heme monooxygenases essential for bacterial steroid degradation 9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE): excellent markers for lipid peroxidation 9-LIPOXYGENASE OXYLIPIN PATHWAY IN PLANT RESPONSE TO BIOTIC STRESS A Function of Cytochrome b5 in Fatty Acid Desaturation by Rat Liver Microsomes single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation A Novel Cytochrome b5-like Domain Is Linked to the Carboxyl Terminus of the Saccharomyces cerevisiae D-9 Fatty Acid Desaturase A Study of the Fatty Acid Metabolism of the Yeast Pityrosporum ovale AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs (Supplementary) An isothermal induction of Delta9-desaturase in cultured carp hepatocytes Applications of Stereospecifically-Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases Biochemical and physiological function of stearoyl-CoA desaturase Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases Biochemistry of the soluble methane monooxygenase Biosynthesis and Regulation of Microbial Polyunsaturated Fatty Acid Production Catalytic diversity of fatty acid desaturases Cellular Fatty Acid Metabolism and Cancer Changes in the iron coordination sphere of Fe(I1) lipoxygenase-1 from soybeans upon binding of linoleate or oleate Characteristic Features of Hydroxystearic Acid Monolayers at the Air/Water Interface Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates Circulating hydroxy fatty acids in familial Mediterranean fever Control of fatty acid desaturation: a mechanism conserved from bacteria to humans Control of membrane fluidity: the OLE pathway in focus Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis COX-2 Inhibitory Effects of Naturally Occurring and Modified Fatty Acids Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane Current directions for COX-2 inhibition in breast cancer Cutin Monomers: Biosynthesis and Plant Defense Cytochrome P450 Alkane Hydroxylases of the CYP153 Family Are Common in Alkane-Degrading Eubacteria Lacking Integral Membrane Alkane Hydroxylases Cytochrome P450 monooxygenase from Clostridium acetobutylicum: A new a-fatty acid hydroxylase Deciphering the Cryptoregiochemistry of Oleate Delta12 Desaturase: A Kinetic Isotope Effect Study Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes Desaturation reactions catalyzed by soluble methane monooxygenase Dimorphecolic Acid-A Unique Hydroxydienoid Fatty Acid Dioxygen Activation at Non-Heme Diiron Centers: Oxidation of a Proximal Residue in the I100W Variant of Toluene/o-Xylene Monooxygenase Hydroxylase DIRECT EVIDENCE FOR BIOSYNTHETIC RELATIONSHIPS AMONG HYDROCARBONS, SECONDARY ALCOHOLS AND KETONES IN BRASSICA OLERACEA Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects Eight Histidine Residues Are Catalytically Essential in a Membrane-Associated Iron Enzyme, Stearoyl-CoA Desaturase, and Are Conserved in Alkane Hydroxylase and Xylene Monooxygenase Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation Enzymatic functionalization of carbon–hydrogen bonds Epigenetics and cancer treatment Evidence for Protein Radical-Mediated Nuclear Tunneling in Fatty Acid alpha-Oxygenase Evidence linking the Pseudomonas oleovorans alkane omega-hydroxylase, an integral membrane diiron enzyme, and the fatty acid desaturase family Exotic biomodification of fatty acids Exploring the Hydroxylation-Dehydrogenation Connection: Novel Catalytic Activity of Castor Stearoyl-ACP Delta9 Desaturase Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex Fatty acid desaturases: selecting the dehydrogenation channel Fatty acid desaturation: variations on an oxidative theme Fatty acid oxygenase activity of human hair roots FATTY ACID SYNTHESIS BY COMPLEX SYSTEMS THE POSSIBILITY OF REGULATION BY MICROSOMES Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression Fatty Aldehyde and Fatty Alcohol Metabolism: Review and Importance for Epidermal Structure and Function Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects Functional Mimic of Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Mechanistic Implications of Paramagnetic Intermediates in the Reactions between Diiron(II) Complexes and Dioxygen G2A as a receptor for oxidized free fatty acids GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs Histone deacetylases (HDACs): characterization of the classical HDAC family Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes HYDROXYLATION OF 9-HYDROXYSTEARATE BY A SOLUBLE CYTOCHROME P-450-DEPENDENT FATTY ACID HYDROXYLASE FROM BACILLUS MEGATERIUM HYDROXYSTEARATES AS INHIBITORS OF PALMITATE HYDROXYLATION CATALYZED BY THE CYTOCHROME P-450 MONOOXYGENASE FROM BACILLUS MEGATERIUM Hydroxystearic Acids and the Biosynthesis of Unsaturated Fatty Acids Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism Identification of Nine Acetylenic Fatty Acids, 9-Hydroxystearic Acid and 9,10.Epoxystearic Acid in the Seed Oil of Jodina rhombifolia Hook et Arn. (Santalaceae) Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon INHIBITION OF THE MICROSOMAL STEAROYL COENZYME A DESATURATION BY DIVALENT COPPER AND ITS CHELATES Isolation and characterization of 9-lipoxygenase and epoxide hydrolase 2 genes: Insight into lactone biosynthesis in mango fruit (Mangifera indica L.) Isoricinoleic Acid in Semecarpus kurzii Seed Oil Lipid Peroxidation and Lipid Antioxidants in Normal and Tumor Cells Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination Lipid peroxidation: Mechanisms, inhibition, and biological effects Lipid peroxides induce expression of catalase in cultured vascular cells Lipolysis: pathway under construction Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it? Lipoxygenases – Structure and reaction mechanism Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate Mechanism of Selective Inhibition of Human Prostaglandin G/H Synthase-1 and 2 in Intact Cells Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase Mechanisms and Stereochemistry in Fatty Acid Metabolism Metabolic Alterations of Fatty Acids Metabolism of Hydroxy Fatty Acids -VI. Structure of Hydroxy Acids and the Degradation by Escherichia coli K-12 Mixed regiospecificity compromises alkene synthesis by a cytochrome P450 peroxygenase from Methylobacterium populi Models of High-Valent Intermediates of Non-Heme Diiron Alkane Monooxygenases: Electronic Structure of a Bis(mu-oxo)diron(IV) Complex with Locally Low-Spin Metal Centers Molecular mechanisms underlying catalytic activity of delta 6 desaturase from Glossomastix chrysoplasta and Thalassiosira pseudonana (SI1, SI2) Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan New components of the honey bee (Apis mellifera L.) queen retinue pheromone Nitro-fatty acids: novel anti-inflammatory lipid mediators Non-heme iron oxygenases Novel Fatty Acid Dioxygenases of Human and Plant Pathogenic Fungi Nutritional Regulation of Yeast A\-9 Fatty Acid Desaturase Activity Oxylipins: Structurally diverse metabolites from fatty acid oxidation Peroxisome proliferator-activated receptor-g agonists as potential antiinflammatory agents in asthma and chronic obstructive pulmonary disease PHOSPHOLIPID ACTIONS ON PGHS-1 AND -2 CYCLOOXYGENASE KINETICS Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors Production of Eicosanoids and Other Oxylipins by Pathogenic Eukaryotic Microbes Production of Hydroxy Fatty Acids by Biocatalysis Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix Properties of Rat Liver Microsomal Stearoyl-Coenzyme A Desaturase Quantitation of hydroxylated byproduct formation in a Saccharomyces cerevisiae Delta9 desaturating system Reader’s block: Protein factors can regulate gene expression by binding to specifically modified DNA-associated proteins Recent insights into stearoyl-CoA desaturase-1 Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol Regulation of stearoyl-CoA desaturases and role in metabolism Revealing the catalytic potential of an acyl-ACP desaturase: Tandem selective oxidation of saturated fatty acids Selective inhibition of BET bromodomains Stereochemistry of Delta4 dehydrogenation catalyzed by an ivy (Hedera helix) Delta9 desaturase homolog Stearoyl-CoA desaturase-1 and adaptive stress signaling Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer Stereochemical Analysis of Sulfoxides Obtained by Diverted Desaturation STEREOCHEMISTRY IN THE FORMATION OF 9-HYDROXY-10,12-OCTADECADIENOIC ACID AND 13.HYDROXY-9,11-OCTADECADIENOIC ACID FROM LINOLEIC ACID BY FATTY ACID CYCLOOXYGENASE Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation (Supplementary) Stereospecific Conversion of Oleic Acid to 10-Hydroxystearic Acid Stereospecificity of Microbial Hydrations of Oleic Acid to 10-Hydroxystearic Acid Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2 Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis Subcellular Localization of Membrane-Bound Aryl-Hydrocarbon Hydroxylase and NAD(P)H-Dependent Reductase Activities in Mouse Liver Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production Synthesis of Oleic Acid by Euglena gracilis Terminal Olefin (1-Alkene) Biosynthesis by a Novel P450 Fatty Acid Decarboxylase from Jeotgalicoccus Species The association of desaturase 9 and plasma fatty acid composition with insulin resistance–associated factors in female adolescents The cell division cycle: a physiologically plausible dynamic model can exhibit chaotic solutions The Metabolism of Hydroxystearic Acids in Yeast The multifaceted roles of fatty acid synthesis in cancer The Physiological Role and Control of Mammalian Fatty Acyl-Coenzyme A Desaturases The regulation of Delta-6 and Delta-9 desaturase in the fatty acid metabolism of hepatomas with different growth rate THE REGULATION OF STEAROYL-CoA DESATURASE (SCD) The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol The Stereospecific Conversion of Stearic Acid to Oleic Acid Trichostatin A Is a Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vivo Unraveling the pathway of lipid oxidation in the young pig: Assessment of hepatic β-oxidation and characterization of carnitine palmitoyltransferase I (CPT I) Up-regulated A9-desaturase gene expression by hypolipidemic peroxisome-proliferating fatty acids results in increased oleic acid content in liver and VLDL: accumulation of a Delta9-desaturated metaboliteof tetradecylthioacetic acid X-ray structure of a mammalian stearoyl-CoA desaturase Links More Links Teaching material References
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